Interactions of amphotericin B and SCH 39304 in the treatment of experimental murine candidiasis: lack of antagonism of a polyene-azole combination.

AUTOR(ES)

Sugar, A M

RESUMO

Mice infected intravenously with Candida albicans were treated with SCH 39304, a new triazole antifungal compound, amphotericin B, or both. Two dose levels of each drug were evaluated in an attempt to identify potential helpful or harmful effects on survival and kidney colony counts. Contrary to theoretical predictions, combination therapy was not antagonistic and some additive or synergistic effects were observed. The results obtained in this study suggest that antagonism between polyene and azole antifungal drugs is not inevitable and that additive or synergistic effects may be possible.

Documentos Relacionados

• Treatment of murine cryptococcal meningitis with an SCH 39304-amphotericin B combination.
• Saperconazole therapy of murine disseminated candidiasis: efficacy and interactions with amphotericin B.
• Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304.
• KY-62, a Polyene Analog of Amphotericin B, for Treatment of Murine Candidiasis
• Prophylaxis of murine candidiasis via application of liposome-encapsulated amphotericin B and a muramyl dipeptide analog, alone and in combination.