Interaction of Fat-stimulated Gastric Inhibitory Polypeptide on Pancreatic Alpha and Beta Cell Function

AUTOR(ES)

Verdonk, C. A.

RESUMO

Gastric inhibitory polypeptide (GIP) is considered to be the principal mediator of the enteroinsular axis. A glucose-insulin clamp technique was used to study the effects of differing blood glucose levels on the insulinotropic and glucagonotropic actions of fat-stimulated GIP in seven healthy subjects, as well as the effect of physiologic hyperinsulinemia on GIP secretion. Blood glucose levels were clamped for 4 h at 43±2 mg/dl (hypoglycemic clamp), 88±1 mg/dl (euglycemic clamp), and 141±2 mg/dl (hyperglycemic clamp) in the presence of a constant insulin infusion (100 m U/kg per h).

Documentos Relacionados

• Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors.
• Inhibitory Effects of Leptin on Pancreatic α-Cell Function
• Interaction of cholecystokinin and vasoactive intestinal polypeptide on function of mouse pancreatic acini in vitro.
• Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs.
• Studies of pancreatic alpha cell function in normal and diabetic subjects