Interaction of factor VIII antigen in hemophilic plasmas with human antibodies to factor VIII.

AUTOR(ES)

Zimmerman, T S

RESUMO

By utilizing a simple modification of previous immunological assays, we have demonstrated that most, if not all, hemophilic plasmas contain antigen reactive with human antibodies directed against Factor VIII procoagulant activity (VIIIc). Antibodies developing in a nonhemophiliac patient and in a hemophiliac patient gave similar results. The VIIIc antigen so identified was removed from hemophilic plasmas with immobilized rabbit antibody which reacted with normal VIIIc and von Willebrand's disease antigen. These data suggest that there are greater antigenic similarities between normal and hemophilic Factor VIII than previously thought.

Documentos Relacionados

• Natural antibodies to factor VIII (anti-hemophilic factor) in healthy individuals.
• Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.
• Analysis of factor VIII coagulant antigen in normal, thrombin-treated, and hemophilic plasma.
• Studies on the Nature of Antihemophilic Factor (Factor VIII): FURTHER EVIDENCE RELATING THE AHF-LIKE ANTIGENS IN NORMAL AND HEMOPHILIC PLASMAS
• Pregnancy and antibody to factor VIII.