Interação dos anestesicos locais benzocaina, lidocaina e tetracaina com membranas modelo

AUTOR(ES)
DATA DE PUBLICAÇÃO

1998

RESUMO

Among the theories for the mecanism of action of local anesthetics (LA) we can highlight those explaining LA effects upon the sodium channel protein and those which focus on the effects of LA interaction with the lipid membrane phase. Once a direct correlation among LA hydrophobicity (measured by the partition coefficient) and its clinical potency exists, it is natural to believe that the mechanism of action of LA goes by an interaction with the lipid bilayer. The neutral form of the anesthetics fits better this interpretation because they are more hydrophobic than the protonated (charged) species. When choosing the anesthetics for this work. Benzocaine (BZC, an ester) got our attention because it is always uncharged around the physiologic pH. To compare BZC with other anesthetics, we chose Lidocaine (LDC, an amino-amide) and Tetracaine (an amino-ester) which have been previously studied in our laboratory (de Paula &Schreler, 1995) and possess an ionizable amine around pH 7.4. All the experiments with LDC and TTC were conducted in pH 10.5 where they were totally unchanged. The anesthetic?s hydrophobicity follows the order: LDC

ASSUNTO(S)

anestesia local ressonancia paramagnetica eletronica ressonancia magnetica nuclear

ACESSO AO ARTIGO

Documentos Relacionados