Insulin-like growth factor II stimulates motor nerve regeneration.

AUTOR(ES)

Near, S L

RESUMO

Injury to mammalian motor nerves can lead to paralysis, but relatively successful regeneration may occur when conditions are favorable. Elucidation of the mechanism upholding successful regeneration is of theoretical and clinical interest. In this study, the hypothesis that insulin-like growth factor II (IGF-II) can stimulate motor nerve regeneration was tested. When IGF-II was infused continuously near a site of crush on the sciatic nerve, the distance of motor axon regeneration was increased significantly in rats. In contrast, spontaneous regeneration was inhibited when an anti-IGF-II antiserum was infused through a "window" in the epineurium. Thus, infused IGF-II can increase, and endogenous IGFs can support, the regeneration of motor axons in lesioned nerves.

Documentos Relacionados

• Insulin-like growth factor II stimulates cell proliferation through the insulin receptor
• The receptor for insulin-like growth factor II mediates an insulin-like response.
• Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.
• Insulin-like growth factor II signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells
• Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats.