Innate Immunity to Amebic Liver Abscess Is Dependent on Gamma Interferon and Nitric Oxide in a Murine Model of Disease

AUTOR(ES)

Seydel, Karl B.

FONTE

American Society for Microbiology

RESUMO

Evidence from in vitro studies suggests that gamma interferon (IFN-γ) and nitric oxide (NO) are important in host defense against the protozoan parasite Entamoeba histolytica. We used SCID mice with targeted disruption of the IFN-γ receptor gene and mice with targeted disruption of the gene encoding inducible NO synthase to show that IFN-γ plays a role in the innate immunity to amebic liver abscess seen in SCID mice while NO is required for control of amebic liver abscess in immunocompetent mice.

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