Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide
AUTOR(ES)
Wu, Chang-Jer
FONTE
American Society for Microbiology
RESUMO
Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=434198Documentos Relacionados
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