Inhibition of Protein Synthesis by Polypeptide Antibiotics I. Inhibition in Intact Bacteria
AUTOR(ES)
Ennis, Herbert L.
RESUMO
Ennis, Herbert L. (St. Jude Children's Research Hospital, Memphis, Tenn.). Inhibition of protein synthesis by polypeptide antibiotics. I. Inhibition in intact bacteria. J. Bacteriol. 90:1102–1108. 1965.—The mechanism of inhibition of growth of cells by the polypeptide antibiotics of the PA 114, vernamycin, and streptogramin complexes was studied. This inhibition apparently was due to the selective inhibition of protein synthesis by these antibiotics. Ribonucleic acid synthesis was unaffected by concentrations of the antibiotics which completely inhibited protein synthesis. Deoxyribonucleic acid synthesis was slightly inhibited. These antibiotics are composed of a number of components. Mixtures of equal amounts of PA 114 A and PA 114 B or vernamycin A and Bα were more active in stopping protein synthesis in intact cells than each of the components of the antibiotic complex alone. Mutants resistant to one of the antibiotics were resistant to all of the group and, in addition, were resistant to erythromycin and oleandomycin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=315780Documentos Relacionados
- Inhibition of Protein Synthesis by Polypeptide Antibiotics II. In Vitro Protein Synthesis
- PROTEIN SYNTHESIS BY RETICULOCYTE RIBOSOMES, I. INHIBITION OF POLYURIDYLIC ACID-INDUCED RIBOSOMAL PROTEIN SYNTHESIS BY CHLORAMPHENICOL*
- Water Stress and Protein Synthesis: I. Differential Inhibition of Protein Synthesis 1
- Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits.
- Inhibition of Protein Synthesis in Intact HeLa Cells
