Inhibition of malaria parasite development in mosquitoes by anti-mosquito-midgut antibodies.
AUTOR(ES)
Lal, A A
RESUMO
The mosquito midgut plays a central role in the development and subsequent transmission of malaria parasites. Using a rodent malaria parasite, Plasmodium berghei, and the mosquito vector Anopheles stephensi, we investigated the effect of anti-mosquito-midgut antibodies on the development of malaria parasites in the mosquito. In agreement with previous studies, we found that mosquitoes that ingested antimidgut antibodies along with infectious parasites had significantly fewer oocysts than mosquitoes in the control group. We also found that the antimidgut antibodies inhibit the development and/or translocation of the sporozoites. Together, these observations open an avenue for research toward the development of a vector-based malaria parasite transmission-blocking vaccine.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=186104Documentos Relacionados
- Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship
- Invasion in vitro of mosquito midgut cells by the malaria parasite proceeds by a conserved mechanism and results in death of the invaded midgut cells
- Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies.
- Anti-gamete monoclonal antibodies synergistically block transmission of malaria by preventing fertilization in the mosquito.
- Differential inhibition of Streptococcus mutans in vitro adherence by anti-glucosyltransferase antibodies.