Inhibition of intracellular growth of Listeria monocytogenes by antibiotics.

AUTOR(ES)

Michelet, C

RESUMO

We studied the activities of 15 antibiotics on the intracellular growth of Listeria monocytogenes in a HeLa cell line. After 24 h of contact with the infected cells, the antibiotics most effective against the intracellular growth of the 10 strains tested were amoxicillin, temafloxacin, and sparfloxacin, which nevertheless failed to totally eliminate the intracellular bacteria. Rifampin and co-trimoxazole had variable effects, depending on the isolates studied. The most active combinations were amoxicillin-sparfloxacin, co-trimoxazole-gentamicin, and sparfloxacin-co-trimoxazole. The results suggest the value of using a cell culture technique to study the activities of antibiotics against certain bacteria with intracellular sites of multiplication.

Documentos Relacionados

• Nonspecific Inhibition of Growth of Intracellular Listeria monocytogenes by Lymphocyte Culture Products
• Differential inhibition of bacterial growth and hemolysin production by lincosamide antibiotics.
• Inhibition of DNA replication initiation by aminoglycoside antibiotics.
• Protection by D-amino acids against growth inhibition and lysis caused by beta-lactam antibiotics.
• Inhibition of candidacidal activity of human neutrophil leukocytes by aminoglycoside antibiotics.