Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin.
Paton, J C
The in vitro effects of pneumolysin, a sulfhydryl-activated toxin produced by Streptococcus pneumoniae, on various functions of human polymorphonuclear leukocytes (PMNLs) was investigated. Treatment of PMNLs with highly purified toxin significantly inhibited respiratory burst (in response to stimulation), ability to kill opsonized pneumococci, chemotaxis, and random migration. These inhibitions were observed at very low toxin doses (less than or equal to 1 hemolytic unit (2 ng) per 10(6) PMNLs), which had no effect on PMNL viability. These results suggest that pneumolysin could function in pathogenicity by interfering with the ability of PMNLs to migrate toward and kill pneumococci.
ACESSO AO ARTIGOhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264628
- Suppression of polymorphonuclear leukocyte bactericidal activity by suramin.
- Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin.
- Stimulation of polymorphonuclear leukocyte bactericidal activity by supernatants of activated human mononuclear cells.
- Antibiotic inhibition of the respiratory burst response in human polymorphonuclear leukocytes.
- Bordetella pertussis induces respiratory burst activity in human polymorphonuclear leukocytes.