Inhibition of DNA gyrase by optically active ofloxacin.
AUTOR(ES)
Imamura, M
RESUMO
Inhibition of DNA gyrase activity by optically active ofloxacins was studied and compared with the inhibition of norfloxacin and ciprofloxacin. The (-)-isomer of ofloxacin inhibited the supercoiling activity of gyrase from Micrococcus luteus more effectively than did the (+)-isomer. The 50% inhibitory concentrations of (-)-, (+/-)-, and (+)-ofloxacin; norfloxacin; and ciprofloxacin for gyrase from Escherichia coli were 0.78, 0.98, 7.24, 0.78, and 1.15 microgram/ml, respectively. These values correlated well with the antibacterial activity of each compound against intact bacterial cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=174716Documentos Relacionados
- Synthesis and antibacterial activities of optically active ofloxacin.
- In vitro activity of DR-3355, an optically active ofloxacin.
- In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin.
- In Vitro and In Vivo Antibacterial Activities of Levofloxacin (l-Ofloxacin), an Optically Active Ofloxacin
- Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor.
