Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.

AUTOR(ES)

Kennedy, R C

RESUMO

A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide.

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