Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.
AUTOR(ES)
Tsai, M H
RESUMO
Certain lipids were found to inhibit the interaction between rho and R-ras proteins and their respective GTPase-activating proteins (GAP). Inhibitory lipids were similar for each protein but differed significantly from those previously found to inhibit the interaction between ras protein and GAP activity. These data raise the possibility that ras and related proteins are controlled biologically by interactions between lipids and GAP molecules.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=363684Documentos Relacionados
- Ras GTPase-activating protein physically associates with mitogenically active phospholipids.
- GTPase-Activating Proteins for Cdc42
- Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction.
- Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein
- Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins.