Influencia dos polimorfismos T6235C e A4889G, do gene CYP1A1, e dos haplotipos NAT1*3, NAT1*4 e NAT1*10 do gene NAT1, associados com o metabolismo de carcinogenos, na susceptibilidade ao adenocarcinoma colorretal esporadico / Influence of T6235C and A4889G polymorphisms of the CYP1A1 gene, and NAT1*3, NAT1*4 and NAT1*10 haplotypes of the NAT1 gene, associated with the carcinogens metabolism, in the susceptibility of the sporadic colorectal adenocarcinoma

AUTOR(ES)

Sandro Nunes Angelo

DATA DE PUBLICAÇÃO

2008

RESUMO

The exposure of the cells of the colon and rectum to carcinogenic substances is associated with the consumption of foods that are source of substrates, such as aromatic amines and polycyclic aromatic hydrocarbons. Enzymes such as cytochrome P450 monooxygenase, encoded by the CYP1A1 gene, and acetyltransferase, encoded by the NAT1 gene, are related to the metabolism of these substances. T6235C and A4889G polymorphisms, of the CYP1A1 gene, and NAT1*10 haplotype of the gene NAT1 were associated with incidence of colorectal cancer (CC). There are no descriptions about the influences of these polymorphisms on the risk for the CC in our population, which is the objective of the study. DNA from 254 sporadic colorectal adenocarcinoma (SCA) patients and 255 controls were analysed by polymerase chain reaction and restriction digestion. It was also assessed the dietary pattern pacients and controls through the recall of food frequency. There was a greater risk of the occurrence of SCA in individuals with the variant genotypes of the T6235C and A4889G polymorphisms, of the CYP1A1 gene, associated with high consumption of meat. The frequency of the NAT1*10 haplotype was greater in pacients than in controls, with increased risk of occurrence of SCA these individuals. Increased risk of occurrence of the disease was also observed in individuals with NAT1*10 haplotype of the gene NAT1 and excessive consumption of meat and little vegetables and fruits. The results of the study suggest that the pathaway inherited from the metabolism of carcinogens, CYP1A1 and NAT1, associated with the pattern of diet influences the risk of occurrence of SCA in our country

ASSUNTO(S)

haplotipos polymorphism polimorfismo haplotypes

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