Influência do transplante renal e de polimorfismos genéticos nos níveis de proteína C reativa em pacientes com doença renal crônica / Influence of kidney transplantation and single-nucleotide polymorphisms on C - reactive protein levels in chronic kidney disease patients

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

We evaluated the influence of kidney transplantation (Tx), as well as single nucleotide polymorphisms (SNPs) in the "C" reactive protein (CRP) gene promoter region on CRP levels in 50 patients with chronic kidney disease under dialysis. CPR levels were evaluated at pre-Tx, as well as during the first and second years post-Tx. Initially, patients were divided into tree groups according to pre-Tx CRP percentiles (25, 50 and 75). At the same time, we evaluated the genotypes for 2 SNPs, a bi-allelic (G->A) at the -409 position and a tri-allelic (C->T->A) at the -390 position. In general analysis, CRP levels was significantly reduced in the first year and increased, not significantly, in the second year post Tx. Upon dividing the groups, the patients with CRP levels under the normal range (25th and 50th percentiles) presented stable, whereas there was a progressive and significant reduction in the post Tx CRP levels in patients in the 75th percentile (p=0.002). All patients presented the -409GG genotype. When evaluated for the -390 position, the "A" allele was not found and there were 15 "CC" pts, 11 "TT" and 24 "CT". CRP general means were different among patients with different genotypes (p=0.019). Also, allele "T" presence was associated with higher CRP levels in the pre-Tx (p=0.007) and first year post (p=0.001), but not at the second year post-Tx (p=0.146). We concluded that Tx reduces CRP levels in patients with previously high CRP. SNPs at the -390 position of the CRP gene promoter region influence CRP´s basal levels in such a way that the "C" allele correlates with the lowest and the "T" with the highest. We did not observe this influence in our patients at the second year post-Tx.

ASSUNTO(S)

inflamação polymorphism single nucleotide c-reactive protein inflammation kidney failure chronic falência renal crônica kidney transplantation proteína c reativa polimorfismo de um único nucleotídeo transplante de rim

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