Influencia de ions manganes sobre os efeitos dos venenos das serpentes Crotalus durissus terrificus e Bothrops jararacussu / Effects of manganese ( Mn POT.2+ ) on the neurotoxic and myotoxic activities caused by Crotalus durissus terrificus and Bothrops jararacussu venoms in chick biventer cervicis preparations

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

In this study, we examined the effects of Mn2+, a neuromuscular blocker with pre and postsynaptic actions, on the neurotoxicity and myotoxicity induced by Crotalus durissus terrificus and Bothrops jararacussu venoms in chick biventer cervicis preparations. Pretreating the preparations with Mn2+ (0.66 or 1.6 mM) did not affect the blockade induced by C. d. terrificus venom or KCl-induced contractures, but partially reduced ACh-induced contractures. On the other hand, both concentrations of Mn2+ partially prevented the blockade induced by B. jararacussu venom (seen after washing the preparations with Krebs solution), whereas only 1.6 mM Mn2+ significantly restored ACh-induced contractures. Pretreatment with Mn2+ (1.6 mM) partially prevented the muscle damage and the release of creatine kinase induced by both venoms. These results show that Mn2+ did not prevent the neurotoxicity of Cdt venom, but partially reduced its myotoxicity, whereas this metal partially attenuated the myotoxicity and neuromuscular blockade caused by B. jararacussu venom. The pre- and postsynaptic actions of Mn2+ may be useful for studying snake venoms that show one or both of these activities

ASSUNTO(S)

snake venoms neurotoxinas neurotoxic agents agentes neurotoxicos venenos de serpentes neurotoxins neuromuscular junction junção neuromuscular

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