Influência das HSPs (heat shock proteins) e do mTORC-1 (mammalian target of rapamycin complex 1) na regeneração de músculos esqueléticos. / Influence of HSPs (heat shock proteins) and mTORC1 (mammalian target of rapamycin complex 1) in skeletal muscle regeneration.

AUTOR(ES)

Talita Cristiane Conte

DATA DE PUBLICAÇÃO

2009

RESUMO

The goal of this work was to contribute to a better understanding about the intracellular mechanisms involved in skeletal muscle regeneration by studying the influence of heat shock proteins (HSPs) and mTORC1 (mammalian target of rapamycin complex 1) in the muscle regeneration process. The treatment with radicicol (a HSP inductor) in injured muscles induced increase of myofiber cross section area at 10 and 21 days post lesion and increased number of satellite cells and differentiating myofibers at 1 and 10 days post lesion, respectively, when compared to their respective injured controls. The treatment with rapamycin (a mTORC1 inhibitor) in injured muscles induced a more accentuated decrease in myofiber cross section area at 10 and 21 days post lesion and decreased muscle protein synthesis at 10 days post lesion when compared to only-injured muscles. Our results suggest that HSPs and mTORC1 are important to the process of skeletal muscle regeneration.

ASSUNTO(S)

hsp hsp muscle proteins skeletal muscle (regeneration) crotoxin músculo esquelético (regeneração) crotoxina m torc-1 mtorc-1 proteínas musculares

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