Influencia da ciclosporina-A e nifedipina sobre a perda ossea alveolar na periodontite induzida em ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

Immunosuppressive agents have been recognized as a factor affecting the soft tissues of the periodontium. However, little is known about their effect on periodontitis progression. The aim of the present study was to investigate the influence of CsA and nifedipine, associated or not, on the bone loss resulting from a ligature-induced periodontitis in rats. Twenty-four adult male Wistar rats were included. After anesthesia, the mandibular molar was randomly assigned to receive the cotton ligature in the sulcular area while the contralateral tooth was left unligated. The animais were randomly assigned to one of the following daily treatments: Group A - saline solution and dimethyl sulfoxide, Group B ? CsA (10mg/kg), Group C - nifedipine (50mg/kg) and Group D - CsA (10mg/kg) plus nifedipine (50mg/kg). Forty-five days later, the animais were sacrificed and the specimens routinely processed for serial decalcified sections. Intergroup analysis did not reveal significant differences regarding the bone IOS5 volume in the ligated teeth between the experimental treatments (0.46 .:!: 0.11, 0.63 .:!: 0.32, 0.53 .:!: 0.14, 0.50 .:!: 0.18, for groups A, B, C and D respectively - P>0.05). However, intragroup analysis showed a greater bone los5 volume in the ligated teeth than in the unligated ones (P<0.05). Within the limits of the present study, the administration of CsA and nifedipine,associated or not, may not influence bone loss in ligature induced periodontitis in rats

ASSUNTO(S)

imunossupressão medicamentos - administração rato

ACESSO AO ARTIGO

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