Influence of the female sexual hormones about the pulmonary allergic inflammation in model murino of chronic asthma. / Influência dos hormônios sexuais femininos sobre a inflamação alérgica pulmonar em modelo murino de asma crônica.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

We evaluated the influence of female sex hormones on the pulmonary alergic asthma in a experimental chronic asthma model.Groups: Basal, (non-manipulated animals), Ovx (Ovariectomized) and Sham- Ovx/ allergic ( animals subjected to similar manipulations except for the ovaries removal) sensitized 7 days after ovarietcomy and challenged with OVA after the 21st Day, OVX+P/allergic, treated with progesterone (200 µg/Kg) 24h before sensitization or OVx+E/allergic treated with estradiol (300 µg/Kg) 4h before sensitization and the realized challenges, according to the protocol of Ovx animal. Our results showed that the ovarietomy (Ovx) reduces cell migration towards the lungs in OVx groups when compared to the Sham-OVx/allergic group. The treatment with estradiol increased the total number of cells in the Ovx+E/alleric group, while the treatment with progesterone in the OVx+P/allergic group reduced cell migration towards the lung. About the quantification of mucus in the airways, we observed the reduction of mucus and collagen in the OVx group comparing to the non-treated group.

ASSUNTO(S)

estrógenos asthma estrogens inflammation progesterone mice camundongos pulmão asma inflamação lung progesterona

ACESSO AO ARTIGO

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