Influence of Carbon Dioxide on the MIC of Telithromycin for Streptococcus pneumoniae: an In Vitro-In Vivo Study

AUTOR(ES)

Batard, Eric

FONTE

American Society for Microbiology

RESUMO

Incubation in CO2 resulted in higher (≥3 doubling dilution) MICs of telithromycin than those found in ambient air for 31.2% of 346 Streptococcus pneumoniae ermB-positive strains. An increased telithromycin MIC in CO2 was not correlated with loss of its activity in the murine sepsis/peritonitis model.

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