Influence of alpha thalassaemia on the retinopathy of homozygous sickle cell disease.
AUTOR(ES)
Fox, P D
RESUMO
Homozygous alpha+ thalassaemia (alpha-/alpha-) ameliorates some of the clinical manifestations of homozygous sickle cell (SS) disease but its effect on retinal complications remains unknown. This has been assessed by visual examination and fluorescein angiography in 39 subjects with SS disease and homozygous alpha+ thalassaemia and in 39 age/sex matched controls with SS disease but with a normal alpha globin genotype (alpha alpha/alpha alpha). The results indicate that homozygous alpha+ thalassaemia reduces the extent of peripheral retinal vessel closure but has no apparent effect on the frequency of proliferative sickle retinopathy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=504436Documentos Relacionados
- Alpha thalassaemia and the macular vasculature in homozygous sickle cell disease.
- Negro alpha-thalassaemia: genetic studies in homozygous sickle cell disease.
- Blood rheology and proliferative retinopathy in homozygous sickle cell disease.
- Haematological factors associated with proliferative retinopathy in homozygous sickle cell disease.
- Antiphospholipid antibodies in homozygous sickle cell disease.