Ineffectiveness for infants of immunization of mothers with pneumococcal capsular polysaccharide vaccine during pregnancy
AUTOR(ES)
Lopes, Claudia R.C., Berezin, Eitan N., Ching, Ting Hui, Canuto, Jaildo de Souza, Costa, Vanilda Oliveira da, Klering, Érika Monteiro
FONTE
Brazilian Journal of Infectious Diseases
DATA DE PUBLICAÇÃO
2009-04
RESUMO
Pneumococcal (Pnc) carriage is associated with pneumococcal diseases. Breast feeding and maternal vaccination may be a useful approach to prevent pneumococcal infection in young infants. We examined the risk of Pnc carriage by infants at six months of age after pneumococcal polysaccharide vaccination of pregnant women. We selected 139 pregnant woman. The woman were randomly allocated to receive 23-valent polysaccharide vaccines during pregnancy (Group 1) after pregnancy (Group 2) or not receive any vaccine (Group 3). Nasopharyngeal swabs were collected from the infants at three and six months of age. The infants were evaluated monthly during the first six months. We included 47 mothers in Group 1, 45 mothers in Group 2 and 47 mothers in Group 3. Forty-seven percent of the babies were exclusively breast fed until six months, 26% received both breast feeding and artificial feeding and 13% received only artificial feeding. Among those patients, 26% were colonized by Pnc at six months (12 from Group 1, 13 from Group 2, and 12 from Group 3). There was no significant difference in colonization between the three groups. Thirty percent of the children were colonized by a non-susceptible strain. We concluded that young infants (three months old) are already susceptible to pneumococcal carriage. Vaccination during pregnancy with a polysaccharide vaccine did not decrease Pnc colonization.
Documentos Relacionados
- IMMUNIZATION OF RABBITS WITH PERIODATE-OXIDIZED PNEUMOCOCCAL TYPE VI SPECIFIC CAPSULAR POLYSACCHARIDE COUPLED TO HORSE ANTIBODY
- Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients
- Antibody response to serogroup A and C meningococcal polysaccharide vaccines in infants born of mothers vaccinated during pregnancy.
- Pneumococcal polysaccharide immunization.
- Serum Opsonic Activity in Infants with Sickle-Cell Disease Immunized with Pneumococcal Polysaccharide Protein Conjugate Vaccine