Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.
AUTOR(ES)
Dockrell, H M
RESUMO
Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=174386Documentos Relacionados
- Recognition of mycobacterial antigens by sera from patients with leprosy.
- Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance.
- Th1 Cytokine Patterns in Cervical Human Papillomavirus Infection
- Th1 and Th2 responses: what are they?
- Recombinant human growth hormone modulates Th1 and Th2 cytokine response in burned mice.
