Induction of nonspecific tolerance to endotoxins reduces the alveolar bone resorption in ligature-treated rats.
AUTOR(ES)
Nowotny, A
RESUMO
Previous experimental data from various laboratories indicate that endotoxin of gram-negative oral microorganisms might be one of the most important bacterial products involved in bone resorption during periodontitis. Immunologically nonspecific tolerance to endotoxins in rats was induced by repeated application of Serratia marcescens trichloroacetic acid-extracted endotoxin. Silk ligature was placed on the second maxillary molar of the endotoxin-tolerant rats as well as of control rats in which tolerance to endotoxin had not been induced. The animals were sacrificed 8 days later. The rats showed no specific immune response to the tolerance-inducing endotoxin as measured by passive hemagglutination and by the lymphoblast assays, but we found that bone resorption was significantly reduced in the endotoxin-tolerant rats as compared with ligature-treated animals in which tolerance to endotoxin had not been induced.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=348029Documentos Relacionados
- Resorption of implanted bone prepared from normal and warfarin-treated rats.
- Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats.
- Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats
- Influence of alcohol consumption on alveolar bone level associated with ligature-induced periodontitis in rats
- Induction of antigen-specific immunity and tolerance to Mycobacterium leprae in Lewis rats.