Inclusion complex of the antiviral drug acyclovir with cyclodextrin in aqueous solution and in solid phase

AUTOR(ES)

Rossel, Carlos von Plessing, Sepúlveda Carreño, Jacqueline, Rodríguez-Baeza, Mario, Alderete, Joel Bernabé

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2000-12

RESUMO

Complexation between acyclovir (ACV), an antiviral drug used for the treatment of herpes simplex virus infection, and beta-cyclodextrin (beta-CD) was studied in solution and in solid states. Complexation in solution was evaluated using solubility studies and nuclear magnetic resonance spectroscopy (¹H-NMR). In the solid state, X-ray diffraction, differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) and dissolution studies were used. Solubility studies suggested the existence of a 1:1 complex between ACV and beta-CD. ¹H-NMR spectroscopy studies showed that the complex formed occurs with a stoichiometry ratio of 1:1. Powder X-ray diffraction indicated that ACV exists in a semicrystalline state in the complexed form with beta-CD. DSC studies showed the existence of a complex of ACV with beta-CD. The TGA studies confirmed the DSC results of the complex. Solubility of ACV in solid complexes was studied by the dissolution method and it was found to be much more soluble than the uncomplexed drug.

Documentos Relacionados

• Spectroscopic study of Tb3+(beta-diketonate)3: alpha-cyclodextrin inclusion compounds in aqueous solution
• Preparation and Characterization of the β-Cyclodextrin Inclusion Complex with Benzbromarone
• Quercetin/β-Cyclodextrin Solid Complexes Prepared in Aqueous Solution Followed by Spray-drying or by Physical Mixture
• Preformulation Study of the Inclusion Complex Irbesartan-β-Cyclodextrin
• Imiquimod/β-Cyclodextrin Inclusion Complex: Experimental and Theoretical Studies