In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.
AUTOR(ES)
Koprowski, H
RESUMO
The purpose of this study was to investigate the induction of inducible nitric oxide synthase (iNOS) mRNA in the brain tissue of rats and mice under the following experimental conditions: in rats infected with borna disease virus and rabies virus, in mice infected with herpes simplex virus, and in rats after the induction of experimental allergic encephalitis. The results showed that iNOS mRNA, normally nondetectable in the brain, was present in animals after viral infection or after induction of experimental allergic encephalitis. The induction of iNOS mRNA coincided with the severity of clinical signs and in some cases with the presence of inflammatory cells in the brain. The results indicate that nitric oxide produced by cells induced by iNOS may be the toxic factor accounting for cell damage and this may open the door to approaches to the study of the pathogenesis of neurological diseases.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=46229Documentos Relacionados
- Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.
- Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.
- Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.
- Coronavirus-Induced Demyelination Occurs in the Absence of Inducible Nitric Oxide Synthase
- Inducible nitric oxide synthase expression in chronic viral hepatitis. Evidence for a virus-induced gene upregulation.