In vitro susceptibility assessment of agents of the chromoblastomycosis againts different antifungals, isolated and combination (association) / Avaliação da sensibilidade in vitro de agentes causadores de cromoblastomicose frente a diferentes antifúngicos, isolados e associados

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

The aim of the present work was to study the action of several antifungals isolated and combined with amphotericin B against sequential or non-sequential samples in patients infected with chromoblastomycosis and treated or not treated. Thirty nine strains from 18 patients were isolated and submitted to agar dilution testing containing amphotericin B, cetoconazole, itraconazole, terbinafine, 5-flucytosin, fluconazole or griseofulvin. Based on the CIMs and on the serum levels of these antifungals, the isolates were susceptible to ketoconazole, terbinafine and itraconazole. Only 13 of the isolates were susceptible to amphotericin; seven to 5-FC, two to fluconazole and none to a griseofulvin. Regarding the CFMs two strains were susceptible to AnB, 11 for itraconazole, 20 for ketoconazole and three for 5-FC. Six didnt respond to terbinafine and 38 for fluconazole. The combination of antifungals resulted in mainly additive or indifferent interaction. The study of the sequential isolated sample showed a breaking point for the susceptibility of these agents to itraconazole, corresponding CIMs ≤0,06µg/ml of this azole.

ASSUNTO(S)

combinação de antifúngicos antifungals cromoblastomicose micologia aplicada mycology applied fungos demáceos chromoblastomycosis antifúngicos

ACESSO AO ARTIGO

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