In vitro study about the anticariogenic potential of Azadirachta indica (Neem) / Estudo in vitro sobre o potencial anticariogenico de extratos de Azadirachta indica (Nim)

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

The Azadirachta indica A. Juss. (Neem) is a tropical tree native to the Indian continent. It is used in India and Asia for many years as a tool for keeping teeth and gums healthy. This in vitro study evaluated the anticariogenic potential of seed and leaf extracts of Azadirachta indica (Neem). For this purpose, 80 bovine dental fragments were randomly divided in 9 groups of 9 specimens (with the exception of the group 9 which had 8 specimens): group 1 ? Sterile distilled water; group 2 - Chlorhexidine gluconate mouthwash (0.12%); group 3 ? Neem dentifrice; group 4 ? 0.5% Neem Emulsion; group 5 ? 1% Neem Emulsion; group 6 ? 5% Neem leaf extract ; group 7 - 10% Neem leaf extract; group 8 ? 25% Neem leaf extract; group 9 ? Control (Tween 80 + Tween 20 + water). The blocks were submitted to a demineralization bacterial model using a Streptococcus mutans (PS14 strain) for 18 hours. Then, the blocks were analyzed for surface mineral loss (microhardness and Phosphorus analysis) and pH. For microhardness, no statistical difference was observed between Chlorhexidine gluconate mouthwash, Water, Neem dentifrice, 10% and 25% Neem leaf extracts. For pH, no statistical difference was observed between Chlorhexidine gluconate mouthwash and Neem dentifrice. For the Phosphorus analysis, the Neem dentifrice not displayed a statistical difference between Water, 10% and 25% Leaf extracts groups. Nevertheless, all groups were differently from Chlorhexidine gluconate mouthwash (p<0.05%). The results shows that the Neem extracts used in this in vitro study do not show anticariogenic activity

ASSUNTO(S)

dental enamel perda mineral mineral loss esmalte dentario streptococcus mutans

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