In Vitro Reversion of Amphotericin B Resistance in Leishmania donovani by Poloxamer 188
AUTOR(ES)
Espuelas, S.
FONTE
American Society for Microbiology
RESUMO
A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90038Documentos Relacionados
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