In Vitro Pharmacodynamic Properties of Three Antifungal Agents against Preformed Candida albicans Biofilms Determined by Time-Kill Studies

AUTOR(ES)

Ramage, Gordon

FONTE

American Society for Microbiology

RESUMO

We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

Documentos Relacionados

• In Vitro Pharmacodynamic Characteristics of Nystatin Including Time-Kill and Postantifungal Effect
• Rates and Extents of Antifungal Activities of Amphotericin B, Flucytosine, Fluconazole, and Voriconazole against Candida lusitaniae Determined by Microdilution, Etest, and Time-Kill Methods
• Pharmacodynamics of metronidazole determined by a time-kill assay for Trichomonas vaginalis.
• Diminished Killing of Pneumococci by Pristinamycin Demonstrated by Time-Kill Studies
• Activities of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with amikacin, against acinetobacters as determined by checkerboard and time-kill studies.