In Vitro Evaluation of Drug Susceptibilities of Babesia divergens Isolates
AUTOR(ES)
Brasseur, Philippe
FONTE
American Society for Microbiology
RESUMO
The susceptibilities of three bovine and two human Babesia divergens isolates to antimicrobial agents were evaluated in vitro by a tritiated hypoxanthine incorporation assay. The MICs at which 50% of isolates are inhibited (MIC50s) for mefloquine (chlorhydrate), chloroquine (sulfate), quinine (chlorhydrate), clindamycin (phosphate), pentamidine (isethionate), phenamidine (isethionate) plus oxomemazine (chlorhydrate), lincomycin (chlorhydrate monohydrate), and imidocarb (dipropionate) were determined. Except for imidocarb, the MIC50s observed for the different isolates were close. Imidocarb and the combination of phenamidine plus oxomemazine exhibited the highest in vitro activity, while antimalarial agents such as mefloquine, choroquine, and quinine were inactive. Other drugs had intermediate activities. The data support further in vitro evaluation of antimicrobial agents active against B. divergens for the improvement of therapeutic strategies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=105548Documentos Relacionados
- In Vitro Antifungal Susceptibilities of Scopulariopsis Isolates
- In Vitro Susceptibilities of Mycoplasma hyopneumoniae Field Isolates
- In vitro susceptibilities of oral bacterial isolates to spiramycin.
- In vitro susceptibilities of clinical isolates of vancomycin-resistant enterococci.
- In vitro antibiotic susceptibilities of Neisseria gonorrhoeae isolates in the Philippines.