In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
AUTOR(ES)
Marques, Thiago Henrique Costa, Melo, Cássio Herbert Santos de, Freitas, Rivelilson Mendes de
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
14/06/2012
RESUMO
Acute toxicity, antioxidant activity in vitro and general pharmacological effects of the flower crude ethanolic extract of Bellis perennis L., Asteraceae, a popular medicine used in South America, were investigated in mice. The oral route LD50 value was found 2.31 g/kg. Oral administration at doses 50, 100 and 150 mg/kg of the extract neither caused significant changes in general behavior nor led to toxic symptoms. Anxiolytic-like properties were studied in the open field test and the possible antidepressant-like actions were evaluated in the forced swimming test (FST). There is a significant decrease in the number of crossings at all dosages mentioned above, but no sedative effects at any dosages when compared to controls. In the FST, the extract dosage of 150 mg/kg was effective in reducing immobility, along with a significant increase in swimming time. The ethanolic extract showed strong antioxidant potential in vitro, through the removal capacity against hydroxyl radicals and nitric oxide as well as prevented the formation of reactive substances to thiobarbituric acid (TBARS). Together, these results indicate that the ethanolic extract has effect on central nervous system, which might due to its antioxidant property, as demonstrated in vitro methods used. These results suggest that some of the components in ethanolic extract of B. perennis, such as alkaloids, phenolic compounds and flavonoids may have antioxidant, anxiolytic and antidepressant-like properties. Additional investigations are in progress.
Documentos Relacionados
- Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents
- Antidepressant-like effects of an apolar extract and chow enriched with Nepeta cataria (catnip) in mice
- Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
- Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice
- Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors