In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus
AUTOR(ES)
Carriel-Gomes, Márcia Cristina, Kratz, Jadel Müller, Barracco, Margherita Anna, Bachére, Evelyne, Barardi, Célia Regina Monte, Simões, Cláudia Maria Oliveira
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
04/04/2007
RESUMO
Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.
Documentos Relacionados
- Antiviral activity of SK&F 21681 against herpes simplex virus.
- Antiviral Activity of 2-Acetylpyridine Thiosemicarbazones Against Herpes Simplex Virus
- In vitro activity of ketoconazole against herpes simplex virus.
- Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus
- Antibody and interferon act synergistically to inhibit enterovirus, adenovirus, and herpes simplex virus infection.
