In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

AUTOR(ES)

Evina, Jean Noel, Bikobo, Dominique Serge Ngono, Zintchem, Auguste Abouem A., Nyemeck II, Norbert Mbabi, Ndedi, Esther Del Florence Moni, Diboué, Patrick Hervé Betote, Nyegue, Maximilienne Ascension, Atchadé, Alex de Théodore, Pegnyemb, Dieudonné Emmanuel, Koert, Ulrich, Bochet, Christian G.

FONTE

Rev. bras. farmacogn.

DATA DE PUBLICAÇÃO

2017-12

RESUMO

ABSTRACT A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[β-xylopyranosyl-(1→3)-β-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6"-O-acetylvitexin, quercetin 3-O-β-D-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 µg/ml.

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