In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of a Novel Nitro-derivative

AUTOR(ES)

Muelas-Serrano, Susana, Le-Senne, Ana, Fernández-Portillo, Carlos, Nogal, Juan José, Ochoa, Carmen, Gómez-Barrio, Alicia

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2002-06

RESUMO

Nitroarylidenemalononitriles and their cyanoacetamide derivatives with remarkable anti-epimastigote properties, were synthesized attempting to obtain new 3,5-diamino-4-(5'-nitroarylidene)-4H-thiadiazine 1,1-dioxide derivatives, which in previous reports had shown anti-Trypanosoma cruzi activity. Tests to evaluate the cytotoxicity of compounds were performed on J774 macrophages. 5-nitro-2-thienyl-malononitrile (5NO2TM), was the only product which maintained a high anti-epimastigote activity at concentrations in which it was no longer cytotoxic, thus it was assayed against intracellular amastigotes. Its anti-amastigote activity was similar to that of nifurtimox. Afterwards in vivo toxicity and anti-chagasic activity were determined. A reduction in parasitemia was observed.

Documentos Relacionados

• Avaliação in vivo da atividade anti-Trypanosoma cruzi de derivados nitroimidazólicos
• Anti-Trypanosoma cruzi Activity of Green Tea (Camellia sinensis) Catechins
• Evaluation of in vitro anti-Trypanosoma cruzi activity of medications benznidazole, amiodarone hydrochloride, and their combination
• Anti-Trypanosoma cruzi inconclusive results in blood donor screening
• Substâncias da natureza com atividade anti-Trypanosoma cruzi