In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I.
AUTOR(ES)
Petersen, P J
RESUMO
The activity of LJC10,627 was compared with the activities of imipenem and other antibiotics. LJC10,627 was more active against most members of the family Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. but slightly less active than imipenem against staphylococci and streptococci. LJC10,627 showed stability to mouse dehydropeptidase I and was more effective in vivo than imipenem plus cilastatin against gram-negative bacterial infections and as effective against staphylococcal infections.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=244971Documentos Relacionados
- In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I.
- Renal dehydropeptidase-I stability of LJC 10,627, a new carbapenem antibiotic.
- In vitro activity and beta-lactamase stability of LJC 10,627.
- In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I.
- Stability of New Carbapenem DA-1131 to Renal Dipeptidase (Dehydropeptidase I)
