Imunoperoxidase nos linfomas não hodgkin diagnosticados na Universidade Estadual de Campinas

AUTOR(ES)

Francisco Jose Penteado Aranha

DATA DE PUBLICAÇÃO

1995

RESUMO

The non-Hodgkin lymphomas belong to a group of nosologic entities which present ordinary characteristics in relation to both clinical and histology, being in general divided into high and low levels of malignity. The systematization of the many subtypes of the non-Hodgkin lymphomas has been a great problem. Only in the 70 s, in the light of the immunological knowledge and due to a better understanding of their physiopathology, a more adequate classification was reached. Among all, Kiel classification was chosen, since it is in accordance of relationship between the non-Hodgkin lymphomas with the lymphocyte ontogenesis, as it presents a good receptivity among hemopathologists as well as presenting a good clinical correlation. Eighty nine cases ofnon-Hodgkin lymphomas which were diagnosed at the Pathological Anatomy Department at UNICAMP, from 1978 to 1986 were studied. Only through the use oftraditional morphology, 72 cases (80,9%) as non-Hodgkin lymphomas ofB-cell origin and 12 cases (13,5%) as non-Hodgkin T-celllymphomas. Five cases (5,6%) of lymphoblastic lymphoma could not be classified as non-Hodgkin lymphoma neither as B nor as T and were considered indeterminate. In 63 cases (71%) the immuno-histochemical study with monoclonal antibodies L26 (CD 20) and UCHL-i (CD45RO), pan B and pan T, respectively, was carried out: with the monoclonal antibodies pan B 46 positive cases (73%) were Gbtained; with the monoclonal UCHL-l antibodies 6 positives cases were established; 11 cases (17,5%) presented no reaction. With addition of immunoperoxydase reaction to the usual coloration of Pathology laboratory it was possible to define the cellular origin of the non-Hodgkin lymphoma in 11 cases (12,7%), where the morphological impression proved to be insufficient. The histologycal and immunophenotypic subtypes of non-Hodgkin lymphomas in our registered cases are globally equivalent to the first world countries findings. Furthermore, even the utilization of a reduced immuno-histochemical panel allowed the classification of phenotypes in the great majority of the cases

ASSUNTO(S)

linfoma não cancer hodgkin

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