Impacto do encaminhamento para ambulatório de câncer hereditário na qualidade de vida de pacientes portadores de câncer de mama / Impact of hereditary breast cancer risk evaluation on the quality of life of life of patients diagnosed with breast cancer

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Here we evaluated the “impact of breast cancer hereditary cancer risk evaluation’ on the quality of life in a population of breast cancer patients, as measured by the EORTC questionnaires QLQ-C30 and QLQ-BR23. Of the 282 invited patients, 272 agree to participate and answered QLQ before and after the risk determination by Frank, Evans and BRCAPRO methods. High risk was defined as at least 10%. Overall 198 pts completed the study. In the 180 evaluable patients, median age was 53 (+11,5) years old and time since diagnosis was less than 36 months in 89. We did not detected significant differences in quality of life parameters after risk determination, except for negative body image and mastectomy/conservative surgery (p<0.001) There were 45 patients classified as high risk by Frank, 35 by the BRCAPRO and 21 by Evans, agreement being reached in 12. We conclude that pts wish to know about their hereditary breast cancer risk, and this do not cause necessarily more stress. Apart from that, there is a need for local methods of risk calculation.

ASSUNTO(S)

gene brca2. gene brca2 qualidade de vida hereditariedade gene brca1 risk factors quality of life neoplasias mamárias breast neoplasms fatores de risco gene brca1

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