Impact of Gestational Age and Birth Weight on Amikacin Clearance on Day 1 of Life

AUTOR(ES)

Schreuder, Michiel F.

FONTE

American Society of Nephrology

RESUMO

Background and objectives: Intrauterine growth restriction (IUGR) and prematurity are associated with a low nephron endowment. It can therefore be expected that neonates who are born premature and/or after IUGR have a lower GFR. Measurement of GFR in neonates is difficult, but the clearance of amikacin has been proven to be a reliable marker. We hypothesized that amikacin clearance is lower after IUGR or premature birth as a marker of low nephron endowment.

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