Impact of aged donors, HLA compatibility and cold ischemia time on survival rate of cadaver renal transplantation. / Sobrevida de alotransplante renal com doador cadáver relacionada à idade do doador, tempo de isquemia fria e compatibilidade HLA
AUTOR(ES)
Marcelo Ferreira Cassini
DATA DE PUBLICAÇÃO
2009
RESUMO
Introduction: Renal transplantation is world wide recognized as the best therapy for patients that need kidney substitution treatment. It can be considered a clinical and surgical triumph and at the same time, its a form of frustration by the few organs donations available and by the growth of the waiting lists. New strategies are needed to be developed to increase the numbers of kidneys for transplantation. Donors aged, cold ischemia time (CIT) and human leukocyte antigen (HLA) compatibility are correlated with graft survival and consequently, with a diminished organs demand. Objectives: To study the impacts of donors age, cold ischemia time and HLA compatibility, on graft survival patients submitted to cadaver kidney allograft transplantation. Materials and Methods: Records from 454 patients, submitted to cadaver kidneys allograft transplantations between April/1987 and December/2003 by Division of Urology of the Clinical Hospital of Ribeirao Pretos School of Medicine at Sao Paulo University, were analyzed. Results: The age of kidneys donors was the most statistically significant data in the survival graft rate. Donors between 16 and 40 years old had a median survival rate about 143.30 months, that was significantly higher when compared with aged donors above 40 years (66.46 months) (p= 0.005) and below 10 years old (63,29 months) (p= 0.01). In our study, HLA compatibility and cold ischemia time didnt have statistically significant impact on renal allograft survival rate (p= 0.98 and p= 0.16, respectively). Conclusions: HLA compatibility and cold ischemia time didnt have significantly impact on renal allograft survival rate. Donors between 16 and 40 years old can be considered the ideal donors age, since they demonstrated statistically a favorable impact on grafts survival rate.
ASSUNTO(S)
idade do doador cadáver. survival rate cadavers age donor. renal transplantation taxa de sobrevida transplante renal
