Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats

AUTOR(ES)

Andrade, Rodrigo Guimarães, Gotardo, Bruna Magalhães, Assis, Bárbara Cristina A, Mengel, José, Andrade, Zilton A

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2004-11

RESUMO

Systhematized septal fibrosis of the liver can be induced in rats either by repeated intraperitoneal injections of pig-serum or by Capillaria hepatica infection. The relationship between these two etiological factors, as far as hepatic fibrosis is concerned, is not known, and present investigation attempts to investigate it. C. hepatica-induced septal fibrosis of the liver was considerably inhibited in rats previously rendered tolerant to pig-serum. Pig-serum-tolerant rats developed antibodies against pig-serum when infected with C. hepatica, but this did not happen when the infection occurred in normal rats. On the other hand, anti-C. hepatica antibodies failed to recognize any epitope in pig-serum, by Western blot. However, no evidence of an immunological cross reactivity was found, at least at the humoral level. Alternatively, cell-mediated mechanisms may be involved, and further investigations are warranted.

Documentos Relacionados

• Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats
• Worm load and septal fibrosis of the liver in Capillaria hepatica-infected rats
• Dynamics of Capillaria-hepatica-induced hepatic septal fibrosis in rats
• Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
• Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)