Immunological agnosis: a state that derives from T suppressor cell inhibition of antigen-presenting cells.

AUTOR(ES)

Ptak, W

RESUMO

The biologically active mediators of antigen-specific T suppressor cells can combine with antigen on cells that are specialized to present antigen (APC) and render these APC incapable of presenting not only the specific antigen that the product of the T suppressor cell sees but also any other antigen in or on the APC. Thus, antigen-bearing suppressed APC fail to activate either the helper or suppressor system involved in the regulation of contact sensitivity responses. These results demonstrate that APC are targets of T suppressor cells. They also imply that a metabolic event is required for functional antigen presentation and that T suppressor cells can block that metabolic pathway.

Documentos Relacionados

• Immunological tolerance: High-dose antigen-induced suppressor cells from tolerant animals inactivate antigen-presenting macrophages
• T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.
• The specific direct interaction of helper T cells and antigen-presenting B cells.
• Antigen-presenting cells control T cell proliferation by regulating amino acid availability
• Persistence of influenza as an immunogen in pulmonary antigen-presenting cells.