Immunologic studies in asymptomatic hemophilia patients. Relationship to acquired immune deficiency syndrome (AIDS).

AUTOR(ES)

Landay, A

RESUMO

Asymptomatic hemophilia patients receiving Factor VIII concentrate were found to have normal natural killer (NK) cells and B cells, and an inverted T helper/suppressor ratio due to an increase in cells of T suppressor phenotype. In contrast, a hemophilia patient with acquired immune deficiency syndrome (AIDS) exhibited nonfunctional NK cells, low B cells, and an inverted T helper/suppressor ratio due to very low numbers of T helper cells. Hemophilia patients on cryoprecipitate therapy exhibited normal immune parameters. A high percentage of hemophilia patients on both treatments had antibody to hepatitis B virus. The isolated finding of elevated levels of T suppressor cells in hemophilia patients receiving Factor VIII concentrate has not been recognized as an early indicator of impending AIDS, and longitudinal studies will be required to determine its clinical significance.

Documentos Relacionados

• Kaposi's sarcoma in acquired immune deficiency syndrome (AIDS).
• Psychological support and counselling for patients with acquired immune deficiency syndrome (AIDS).
• Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS).
• Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS).
• Organising a counselling service for problems related to the acquired immune deficiency syndrome (AIDS).