Immunohistochemistry analysis of osteosarcoma in patients with and without metastasis and its prognosis correlation / "Análise imunohistoquímica do osteossarcoma em pacientes com e sem metástases e sua correlação prognóstica"

AUTOR(ES)

Marcia Datz Abadi

DATA DE PUBLICAÇÃO

2005

RESUMO

We study, by imunohistochemistry technique, the proteins p53, MDM-2, c-Kit, ErbB-2, PCNA and p-glycoprotein in samples of osteosarcoma tumors at diagnosis and its correlation with the prognosis of this patients. The p-53 was positive in 23,1% (9/39), PCNA in 71,4% (25/35), p-glycoprotein in 40,5% (15/37), MDM-2 in 34,8% (8/23), c-kit in 67,8%(25/37) and ErbB-2 in 17,9% (7/39) of the samples. In the univariate analysis, the presence of metastasis at diagnosis, the positivity of p-53 and ErbB-2 influenced the prognosis individually, otherwise, in the multivariate analysis, the presence of metastasis at diagnosis was the only prgnostic factor statistically significant

ASSUNTO(S)

antÍgeno nuclear de cÉlula em proliferaÇÃo immunohistochemistry/methods prognÓstico receptor erbb-2 glicoproteÍna p prognosis proteÍna p53 receptor erbb-2 osteosarcoma/pathology proliferating cell nuclear antigen imunohistoquÍmica/métodos proteÍna proto-oncogÊnica c-kit osteosarcoma/patologia protein p53 proto-oncogene protein c-kit p-glycoprotein

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