Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction.
AUTOR(ES)
Evans, R T
RESUMO
Adhesive fimbriae from Porphyromonas gingivalis are cell surface structures which may be important in the virulence of this oral pathogen and thus may serve as a critical or target antigen. Immunization with highly purified 43-kDa fimbrial protein protected against periodontal tissue destruction when tested in the P. gingivalis-infected gnotobiotic rat model. A similarly highly purified 75-kDa cell surface component did not provide protection. Heat-killed whole-cell and sonicated cell surface extracts which contain the 43-kDa protein as well as the 75-kDa component were protective also. This study indicates that the fimbrial protein may serve as a model for the development of effective vaccines against periodontitis, a major human oral disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=257256Documentos Relacionados
- Evidence that Porphyromonas (Bacteroides) gingivalis fimbriae function in adhesion to Actinomyces viscosus.
- Biochemical characterization of Porphyromonas (Bacteroides) gingivalis collagenase.
- Protective immunization against experimental Bacteroides (Porphyromonas) gingivalis infection.
- Adherence of Porphyromonas (Bacteroides) gingivalis to Streptococcus sanguis in vitro.
- Immunization with the RgpA-Kgp Proteinase-Adhesin Complexes of Porphyromonas gingivalis Protects against Periodontal Bone Loss in the Rat Periodontitis Model