Immunization of inbred guinea pigs with varicella-zoster virus grown in a syngeneic transformed embryo cell line.
AUTOR(ES)
Grose, C
RESUMO
Varicella-zoster virus was serially propagated in a chemically transformed and cloned line of embryo cells (designated "104 C1") derived from the inbred strain 2 guinea pig. When strain 2 guinea pigs were immunized with varicella-zoster virus subcultivated in the syngeneic cell line, they produced high-titer virus-specific antiserum which lacked antibody against cellular determinants. This immunization procedure offers both practical and theoretical advantages over prior methods which involved inoculation of outbred laboratory animals with varicella-zoster virus grown in allogeneic or xenogeneic cell cultures.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=271940Documentos Relacionados
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