Immune response after rabies oral immunization in mice

AUTOR(ES)

Silva, Camila Sloboda Pacheco da, Krüger, Ernesto Renato, Agottani, Jorge Victor Bacila, Oliveira, Rubens Chaguri de, Pereira, Sandro, Penha, Tânia Regina, Ollhoff, Rüdiger Daniel

FONTE

Braz. arch. biol. technol.

DATA DE PUBLICAÇÃO

25/10/2013

RESUMO

The objective of this study was to formulate an anti-rabies oral vaccine from the cell culture vaccine PV TECPAR to elicit the production of antibodies against the rabies in mice. A vaccine was developed using 10(7.5) DL50/0.03 ml viral antigens homogenised in lanovaseline to facilitate oral administration. Mice were vaccinated two times for seroconversion. Sera of the vaccinated mice showed a higher level of antibody production than the control group. These results could be used to direct the development of an anti-rabies oral vaccine.

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