Identification of the molecular mechanisms associated with acute type A aortic dissection through bioinformatics methods
AUTOR(ES)
Jiang, Tao
FONTE
Braz J Med Biol Res
DATA DE PUBLICAÇÃO
07/11/2019
RESUMO
Aortic dissection is characterized by the redirection of blood flow, which flows through an intimal tear into the aortic media. The purpose of this study was to find potential acute type A aortic dissection (AAAD)-related genes and molecular mechanisms by bioinformatics. The gene expression profiles of GSE52093 were obtained from Gene Expression Omnibus (GEO) database, including 7 AAAD samples and 5 normal samples. The differentially expressed genes (DEGs) were detected between AAAD and normal samples. The functional annotation and pathway enrichment analysis were conducted through the Database for Annotation, Visualization and Integration Discovery (DAVID). A protein-protein interaction network was established by the Search Tool for the Retrieval of Interacting Genes (STRING) software. The microRNAs (miRNAs) of these differentially expressed genes were predicted using
Documentos Relacionados
- Repair of acute dissection of the ascending aorta associated with aortic coarctation.
- Acute Type-B Aortic Dissection in Association with Isthmic Coarctation
- Cerebral Perfusion through Separate Grafts for Repair of Acute Aortic Dissection with Torn Arch
- Coronary Reconnection in Emergency “Conduit Operation” for Acute Type-A Aortic Dissection with Aortic Insufficiency: Experience with 24 Cases
- Outcomes Following Supracoronary Ascending Aortic Replacement with Aortic Valve Resuspension versus Modified Bentall's Operation for Acute Type A Aortic Dissection