Identification of a UV-induced trans-acting protein that stimulates polyomavirus DNA replication.
AUTOR(ES)
Ronai, Z A
RESUMO
Previous studies provided indirect evidence that the ability of a variety of DNA-damaging agents to induce asynchronous polyomavirus DNA replication in the H3 rat fibroblast cell line is mediated by a trans-acting factor. Using an erythrocyte insertion technique to introduce protein fractions from UV-irradiated cells into unirradiated H3 cells, we have now obtained evidence that this factor is a 60-kilodalton protein. These findings provide evidence that DNA damage in mammalian cells induces a factor that can alter the replication of a viral DNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=253667Documentos Relacionados
- UV-induced Hyperphosphorylation of Replication Protein A Depends on DNA Replication and Expression of ATM Protein
- Termination of DNA replication in Escherichia coli requires a trans-acting factor.
- Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replication.
- cis- and trans-Acting Elements in Flavivirus RNA Replication†
- tus, the trans-acting gene required for termination of DNA replication in Escherichia coli, encodes a DNA-binding protein.